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KMID : 1023120110090010025
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Korean Journal of Aesthetic Society
2011 Volume.9 No. 1 p.25 ~ p.34
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Effect of Combined Plant Extracts on Anti-obesity in Rats Fed a High-Fat Diet
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Park Jong-Bae
Lee Hye-Sook
Hwang Seok-Youn
Hong Seung-Bok
Kim Hee-Dong
Yun Chi-Young
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Abstract
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This study was conducted to investigate the anti-obesity of combined plant extracts(Mori folium and Mori cortex radicis, 7:3) in male Sprague-Dawley rats(180 ± 3 g) fed high fat diets for 8 week. Experimental groups were divided into 5 groups; a normal diet group(ND), a high fat diet group(HFD), a high fat diet and combined plant extracts 1% group(HFD+ 1%), a high fat diet and combined plant extracts 3% group(HFD+3%) and a high fat diet and combined plant extracts 5% group(HFD+5%). The body weight of HFD group were heavier than those of ND group, whereas those of groups administered combined plant extracts were gradually decreased after 6 weeks. The activity of serum AST that were significantly increased by the high fat diet were significantly decreased after combined plant extracts administration. Levels of serum triglyceride and LDL-cholesterol significantly reduced in the combined plant extracts administered groups compared with HFD group. There were no differences in the levels of serum total cholesterol and HDL-cholesterol between experimental groups. Theses results suggest that combined plant extracts may inhibit obesity in rat fed HFD.
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KEYWORD
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combined plant extracts, high fat diet, triglyceride, cholesterol
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